FIG. 4.

In vivo kinetics of cryptic epitope-specific responses. The magnitude of responses was tested at various time points during SIV infection. Animals responding to peptides encoded by ARF1 and ARF10 were tested in various acute- and chronic-phase time points. Responses against the RP9 epitope in ARF1 (gray lines) were high frequency in the acute phase but diminished rapidly. In contrast, responses against epitopes in ARF10 (black lines) were detected exclusively in the chronic phase, for unknown reasons. PI, postinfection.