FIG. 3.

KSHV infection abolishes IL-4-stimulated B-cell proliferation in vitro. (A) KSHV-negative (BJAB and DG75) and -positive (BC3, BCBL1, JSC, and BJAB-K) cell lines; (B) BC3 and JSC cells with LANA constitutively knocked down. Cells were seeded in equal amounts and treated with or without 5 ng/ml IL-4 in the presence of LPS. Proliferation was measured at 24, 48, and 72 h after treatment by triplicate cell counting. These experiments were repeated twice, and average results are shown. The P values for comparisons between the untreated and treated groups were calculated by t test.