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Model of NFX1-91 involved in E6-activated NFκB activity. NFX1-91 binds to the p105 promoter and activates p105 expression. E6/E6AP induces degradation of NFX1-91, which reduces expression of p105 and its cleavage product, p50, and possibly induces the formation of NFκB heterodimers lacking p50, such as p65/c-Rel. These NFκB complexes inhibit HPV gene expression.
