Figure 7.1.2.

No-net-flux microdialysis of DA under well-stirred conditions in vitro at 37°C and in vivo in mouse nucleus accumbens (vehicle-treated controls). (A) Plot of the average gain or loss of DA ( $C_{\text{d}}^{\text{in}}-C_{\text{d}}^{\text{out}}$) to or from perfusate and the average linear regression fit of the data: in vitro (open circles), in vivo (filled circles). The slope of the regression line represents the extraction fraction ( $E_{\text{d}}^{\text{ws}}$ in vitro, E_d in vivo). (B) Bar graph of extraction fraction values expressed as the mean ± S.E.M. (*) Denotes significant difference in between in vitro and in vivo measurements. Reproduced with permission from Chefer et al., 2006.