Figure 2.
A genomic map of distal 9p illustrating the deletion or translocation breakpoints in ten 9p deletion patients. The ruler illustrates the first 17 Mb genomic region of 9p. The locations of BAC clones used for FISH are shown below the ruler. Brackets indicate a number of overlapping clones within a less than 2 Mb region. The deletions are arranged from smallest to largest starting at the bottom of the figure. The solid horizontal lines (—) represent genomic regions that are not deleted, the slanted lines (////) represent the breakpoints on 9p and the dotted lines indicate the deleted segment. Vertical lines (||||) represent the breakpoints of the interstitial deletion. The region between two vertical dashed lines represents the previously described critical region for 9p-. The smallest deletion in our patients with clinically relevant phenotypes is indicated by an arrow.