EPM Behavior. Within group A, LCR (n=12) and HCR (n=12) populations spent similar amounts of time in open and closed arms (a), and entered open and closed arms of the maze with similar frequency (b). Group B animals were exposed to restraint stress prior to EPM exposure. HCR (n=11) animals expressed higher levels of anxiety-like behavior, spending less time in open arms, more time in closed arms (c), and entering the open arms of the EPM fewer times than LCR (n=10) animals (d). [* - p < 0.05]