Table 3.
RNA expression of targets assessed by gene expression profiling of 9 LGGs and 6 HGGs
| Target gene (probe ID) | Average intensity HGG | Average intensity LGG | Present in HGG | Present in LGG | Permutation P |
|---|---|---|---|---|---|
| PDGFRβ (1771_at) | 600.4 | 488.8 | 67% | 43% | 0.457 |
| PDGFRα (1731_at) | 9,957.8 | 6,896.0 | 100% | 100% | 0.218 |
| EGFR (1537_at) | 2,389.2 | −41.3 | 67% | 0% | 0.003 |
| EGFR (37327_at) | 987.6 | −39.1 | 33% | 0% | 0.003 |
| AKT1 (1564_at) | 2,402.6 | 388.9 | 67% | 43% | 0.095 |
| p44 MAPK (1000_at) | 1,685.6 | 2,034.0 | 83% | 100% | 0.111 |
| p42 MAPK (976_s_at) | 227.4 | 226.8 | 50% | 57% | 0.994 |
| FRAP1 (267_at) | 111.6 | 98.9 | 50% | 57% | 0.823 |
| FRAP1 (40139_at) | 851.0 | 891.8 | 100% | 100% | 0.772 |
| PDGFB (1573_at) | 48.3 | −110.9 | 0% | 14% | 0.319 |
| PDGFA (35703_at) | 2,388.0 | 828.4 | 83% | 86% | 0.056 |
| PDAP1 (38757_at) | 293.7 | 221.4 | 83% | 14% | 0.372 |
| PDAP1 (38758_at) | 5,055.5 | 2,822.5 | 100% | 100% | 0.001 |
| EGF (1542_at) | 399.0 | 409.9 | 17% | 14% | 0.914 |
| PTEN (1434_at) | 183.9 | 203.9 | 50% | 86% | 0.587 |
| PTEN (39552_at) | 283.0 | 316.3 | 67% | 71% | 0.536 |
| PI3K (36287_at) | 109.3 | 120.4 | 33% | 14% | 0.726 |
| PI3K (35373_at) | 533.5 | 1,742.7 | 67% | 100% | 0.015 |
NOTE: Shaded areas indicate genes with significant (P < 0.01, dark shade) or near-significant (P < 0.10, light shade) differential overexpression by HGG or LGG.