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. 2010 Oct 4;191(1):211–223. doi: 10.1083/jcb.201006039

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© 2010 Xiong et al.

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Figure 6. — Axonal transport is required for regeneration and injury signaling. (A) Inhibition of axonal transport inhibits regeneration after injury. Expression of the p150-Glued dynactin subunit, UAS-Glued^DN, inhibits the formation of new branches at the injury site. (B) Quantitation of the regeneration ratio similar to that in Fig. 4 C. (C) Inhibition of axonal transport inhibits the effect of axon injury on puc-lacZ expression. (D) Ectopic Wnd signaling also requires axonal transport. The induction of puc-lacZ by overexpression (OE) of wnd is suppressed by coexpression of Glued^DN. (E) Quantification of puc-lacZ intensities for genotypes described in C and D. **, P < 0.001; ***, P < 0.0001. Error bars indicate mean ± SEM. Bars, 25 µm.