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. 2010 Oct 4;191(1):211–223. doi: 10.1083/jcb.201006039

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© 2010 Xiong et al.

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Figure 8. — The Hiw E3 ubiquitin ligase negatively regulates injury signaling and regeneration. (A) The hiw^ΔN mutant shows a dramatic increase of puc-lacZ and decrease of DVGLUT intensity in motoneuron cell bodies, and these changes require wnd function. (B) Quantification of puc-lacZ intensity for genotypes in A and when Fos and Glued are inhibited by expressing UAS-Fos^DN or UAS-Glued^DN in the hiw^ΔN;puc-lacZ/+ mutant background. These results suggest that hiw regulates a retrograde signaling pathway. (C) Examples of the proximal stump morphology at different time points after injury. In hiw^ΔN mutants, many injured axons form long new branches within 6 h of injury. In contrast, sprouting is not readily apparent in WT axons until 12 h after injury. (D) Time course of regeneration ratio comparing WT and hiw^ΔN mutants. *, P < 0.05. Error bars indicate mean ± SEM. Bars, 25 µm.