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. 2010 Oct 4;191(1):155–168. doi: 10.1083/jcb.201002100

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© 2010 Di Bartolomeo et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Proposed model of AMBRA1 dynamic interaction with the dynein motor complex during autophagy induction. AMBRA1 is bound in a presumably inactive state to the dynein complex via binding to DLC1. After autophagy induction, AMBRA1 is released from the dynein complex upon ULK1-dependent phosphorylation and translocates to the ER together with BECLIN 1–VPS34 to allow autophagosome formation. The dynein motor complex consists of a Head domain (dynein heavy chain) and a Base domain (DIC, DLC1, or DLC2 and other factors such as TCTEX1 and ROADBLOCK1).