Table 1. Initial set of HIV seed receptors.

Receptor	Receptor type	InterPro domains
Ig-like and Other
CD4	Primary receptor for HIV	AgCD4, CD4-extracel, Ig-like, Ig-likefold, IgC2-set, Igsub, IgV-setsub
7-TM GPCR and CCR rcpt
CCR5	Co-receptor with CD4	7TMGPCRRhodpsn, CC5rcpt
CCR3	Alternative co-receptor with CD4	7TMGPCRRhodpsn, CC3rcpt
CCR2	Alternative co-receptor with CD4	7TMGPCRRhodpsn, CC2rcpt, CC5rcpt
CCR8	Alternative co-receptor with CD4	7TMGPCRRhodpsn, CC8rcpt
CCR9	Alternative co-receptor with CD4	7TMGPCRRhodpsn, CC9rcpt
CXCR4	Alternative co-receptor with CD4	7TMGPCRRhodpsn, CXC4rcpt
CXCR6	Co-receptor	7TMGPCRRhodpsn, CXC6rcpt
CX3CR1	Co-receptor with CD4	7TMGPCRRhodpsn, CX3Cfractrcpt
7-TM GPCR and Other
APJ	Alternative co-receptor	7TMGPCRRhodpsn, APJrcpt
GPR1	Alternative co-receptor	7TMGPCRRhodpsn, GPR1rcpt
Integrin-
ITGA4	Co-receptor with CD4	Intalphabeta-p, Integrinalpha, Integrinalpha-2, IntegrinalphaC
C-type lectin and Other
DC-SIGN	Receptor for HIV	AntifreezeII, C-typelectin

List of seed HIV receptors, including the receptor type and their functional domains. Receptors are grouped according to their functional domains (see Figure 5(a) for the distribution of those domains). A full table including the complete list of references that indicate the association to HIV is provided in Table S5.