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. 2010 Oct 12;5(10):e13139. doi: 10.1371/journal.pone.0013139

Table 2. List of inferred surface membrane factors.

Receptor Receptor-specific InterPro domains Cell types Association with HIV
7-TM GPCR and Other
HTR6 Not applicable Uniform expression1 +
HTR1B 5HT1BInline graphicrcpt Uniform expression1 ?
HTR1E 5HT1FInline graphicrcpt Uniform expression1 ?
RXFP2 LDLInline graphicrcptInline graphicclassAInline graphiccys-richInline graphicrpt, Leu-richInline graphicrpt, LRR-containInline graphicN, Leu-richInline graphicrptInline graphictypical-subtyp, RelaxinInline graphicrcpt Low expression ?
RXFP1 LDLInline graphicrcptInline graphicclassAInline graphiccys-rich, Leu-richInline graphicrpt, LRR-containInline graphicN, Leu-richInline graphicrptInline graphictypical-subtyp, RelaxinInline graphicrcpt No expression profiles available ?
GPR17 P2Inline graphicpurnocptor Uniform expression1 ?
GPR182 G10DInline graphicrcpt Uniform expression1 ?
NPBWR2 NeuropeptInline graphicWInline graphicrcpt Uniform expression1 −
7-TM GPCR and CCR Inline graphic rcpt
CCR1 CCInline graphic1Inline graphicrcpt High expression: whole blood, monocytes, myeloid, dendritic cell +
CCBP2 CXCInline graphic4Inline graphicrcpt Uniform expression1 +/−
7-TM GPCR
DARC DuffyInline graphiccmkInline graphicrcpt High expression: (early) erythroid, endothelial cells +
Ig-like and Other
CD2 AgInline graphicCD2, Ig-likeInline graphicfold, IgInline graphicC2-set, IgInline graphicV-set, T-cellInline graphicsdhesionInline graphicmolcInline graphicCD2 High expression: dendritic, myeloid, monocytes, NK, CD8 and CD4 T cells, whole blood +
CSF3R FNInline graphicIII, HematopoietinInline graphicrcptInline graphicgp130Inline graphicCS, IgC2-likeInline graphiclig-bd High expression: myeloid cells, monocytes and whole blood +
IL1R1 Ig, Ig-likeInline graphicfold, IgInline graphicsub, IL1Inline graphicrcptInline graphic1, IL1RInline graphicrcpt No expression profile available −
CD79B Ig-likeInline graphicfold, IgInline graphicsub, IgInline graphicV-set, PhosInline graphicimmunorcptInline graphicsigInline graphicITAM High expression: CD34, endothelial and dendritic cells +
IL6ST FNInline graphicIII, HematopoietinInline graphicrcptInline graphicgp130Inline graphicCS, Ig-likeInline graphicfold, IgC2-likeInline graphiclig-bd Uniform expression1 +
TNFR Inline graphic Cys Inline graphic rich Inline graphic reg and Other
TNFRSF5 FasInline graphicrcpt High expression: B lymphoblasts +
TNFRSF3 TNFRInline graphic3Inline graphicLTBR High expression: myeloid, monocytes and whole blood +
Other
CD97 EGF-typeInline graphicAsp/AsnInline graphichydroxylInline graphicsite, EGFInline graphicCaInline graphicbdInline graphic2, GPCRInline graphic2Inline graphicCD97, GPCRInline graphic2Inline graphicsecretin-like, GPSInline graphicdom High expression: CD34, B lymphoblast, dendritic cells, CD8 and CD4 T-cells, NK, myeloid, monocytes +
GP1BB LRR-containInline graphicN, Cys-richInline graphicflankInline graphicregInline graphicC High expression: CD34, monocytes and whole blood ?
GYPB Glycophorin High expression: (early) erythroid and endothelial cells ?

List of the potential surface membrane proteins that result from our method, including functional domains and cell types. Predictions that are associated with HIV in earlier studies are marked with ‘+’. ‘−’ indicates predictions with negative evidence. For predictions without literature on interaction the association remains unclear (shown by ‘?’). The list of supporting references is provided in Table S6.

1

Uniform expression in CD34, endothelial, B lymphoblasts, dendritic, myeloid, monocytes, NK, CD8 and CD4 T cells, and whole blood.