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. 2010 Oct 12;5(10):e13262. doi: 10.1371/journal.pone.0013262

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Bhatnagar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Top canonical pathways affected by TNF-α treatment were identified by using IPA analysis. Here the differentially regulated genes with p-value ≤0.05 and fold change ≥1.2 were considered for IPA analysis. Bars represent −log p-value and percentage of genes present in the data set compared to the total number of genes present in each selected pathway in IPA data base. The yellow line represents −log p-value of affected genes to the total number of genes in a pathway. Each bar was represented in two different colors in which red correspond to the up-regulated genes and green corresponds to down-regulated genes. The percentage of up-regulated and down-regulated genes in each selected canonical pathway can be measured in percentage scale given on y-axis (left side).