Table 3. Up-regulated cellular trafficking and protein processing-, immune and stress response-, and transcription-translation-associated genes in hepatic tissue of senior vs. young adult dogs fed an animal protein-based (APB) or plant protein-based (PPB) diet.

			Fold Change
Functional classification	Gene name	Symbol	APB	PPB
Cellular trafficking and protein processing
Transmembrane transport	Peroxisomal membrane protein 69	ABCD4	3.13
Synaptic transmission	Synaptophysin-like 1	SYPL1	2.11
Protein ubiquitination	Ubiquitin-like 1 activating enzyme E1A	SAE1		2.27
Immune and stress response
Immune response	Galectin-2	LGALS2	2.07
Immune response	Ig heavy chain V-III region VH26 precursor	LOC607467		9.66
Transcription-translation
Transcription	Ribosomal protein L6	RPL6	3.53
Telomere maintenance	Telomeric repeat binding factor 2 interacting protein 1	TERF2IP	2.73
Miscellaneous and unknown
Muscle growth	Musculoskeletal, embryonic nuclear protein 1	MUSTN1		64.66
Calcium channel activity	Glycoprotein M6A	GPM6A	8.73	8.32
Fibrinolysis	Annexin A2	ANXA2	7.82
Unknown	FUN14 domain containing 2	FUNDC2		2.45
Unknown	Transmembrane 6 superfamily member 1	TM6SF1	3.82