Table 1. Chemotaxis and motility phenotypes of PI3K-deficient or DOCK2-deficient lymphocytes.

MLN, mesenteric lymph node; N/A, not addressed; PLN, peripheral lymph node; PP, Peyer’s patches; SPL, spleen.

Cell type		Chemotaxis	Localization	Velocity	Turning angle	Motility coefficient	Reference
B	DOCK2	↓		↓34%	Broad	↓93%	[13,23]
	DOCK2/p110γ	Same as	Same as	Same as	Same as	Same as
		DOCK2−/−	DOCK2−/−	DOCK2−/−	DOCK2−/−	DOCK2−/−	[13,23]
	p110γ	↔	↔	↔	↔	↔	[13,14,23]
			↓ Homing to PP
	p110δ	↓	↓ Localization to white    pulp cords	N/A	N/A	N/A	[14]
	p85α	N/A	↔	↓24%	N/A	↓51%	[24]
	p85β	N/A	↔	↓5%	N/A	↓3%	[24]
	Wortmannin	↓	Localization to border of    follicles and T-cell zones	↓21%	N/A		[14,24]
T	DOCK2	↓	↓ Homing to PLN, MLN, PP	↓44%	Broad	↓93%	[13,23]
	DOCK2/p110γ	↓↓	Severe homing defect to all    lymphoid tissue	Similar to DOCK2−/−	Broad	↓96%	[13,23]
	p110γ	↓	↓ Homing to PLN, MLN,    PP, SPL	↔	Slightly broader	↓16%	[13,14,23]
	p110δ	↔	↔	N/A	N/A	N/A	[14]
	p85α	N/A	N/A	↓12%	N/A	↓21%	[24]
	p85β	N/A	N/A	↓26%	N/A	↓56%	[24]
	p85α/p55α/p50 α/p85β	N/A	N/A	↓37%	N/A	↓78%	[24]
	Wortmannin	↓	↔	↓26%*	N/A	↓33%	[19,24]
				↔*

^*Different conclusions in cited references.