Table 1.

Replication and transmission of novel 2009 and seasonal H1N1 viruses in ferrets.

Inoculated Animals						DC Contact Animalsa		RD Contact Animalsa
Virus	Clinical Signs			Virus Detection		Virus Detection	Seroconversiong	Virus Detection	Seroconversiong
	Weight Loss (%)b	Sneezingc	Lethalityd	Lung (peak titer)e	Intestinal Tractf
A/California/04/2009	6/6 (10.3)	2/6	0/6	3/3 (5.8)	5/9 (2.3)	3/3	3/3	2/3	2/3
A/Texas/15/2009	6/6 (9.1)	1/6	0/6	3/3 (6.0)	1/9 (1.3)	3/3	3/3	2/3	2/3
A/Mexico/4482/2009	6/6 (17.5)	3/6	3/6	2/3 (4.1)	2/9 (2.7)	3/3h	3/3	2/3h	2/3
A/Brisbane/59/2007	6/6 (4.9)	6/6	0/6	0/3	0/9	3/3	3/3	3/3	3/3

^aDC, direct contact; RD, respiratory droplet.

^bThe percentage mean maximum weight loss observed during the first 10 days post-inoculation.

^cNumber of animals in which sneezing was observed during the first 10 days post-inoculation.

^dNumber of animals euthanatized before the end of the 14 day experimental period due to reaching a clinical end point.

^eVirus titers are expressed as mean log₁₀ peak PFU/mL or PFU/gram of tissue.

^fVirus titers in intestinal tissue or rectal swabs are expressed as the mean log10 peak PFU/ml for the positive samples.

^gHI antibody titers ranged from 640 to 1280 and were determined using homologous virus and serum collected at least 17 days post contact.

^hVirus was detected in intestinal tract as well as nasal wash for 1 of 3 DC and 2 of 3 RD contact animals.