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. Author manuscript; available in PMC: 2010 Oct 12.
Published in final edited form as: Mol Psychiatry. 2009 Apr 28;15(9):938–953. doi: 10.1038/mp.2009.33

Figure 6.

Figure 6

Tryptophan metabolic pathways. The bold arrow indicates that pathway may be upregulated in first-episode neuroleptic-naive patients with schizophrenia. (1) Tryptophan hydroxylase; (2) Aromatic L-amino acid decarboxylase; (3) Serotonin N-acetyltransferase; (4), 5-Hydroxyindole- O-methyltransferase; (5) Serotonin N-methyltransferase; (6) monoamine oxidase and aldehyde dehydrogenase; (7) Monoamine oxidase; (8) Alcohol dehydrogenase; (9) Tryptophan 2,3-dioxygenase; (10) Formamidase; (11) Kynurenine 3-hydroxylase; (12) Kynurenine transaminase; (13) Kynureninase; (14) 3-Hydroxyanthranilate oxygenase. Also see footnote of Table 2.