Skip to main content
. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: J Neurosci Res. 2010 Nov 15;88(15):3295–3307. doi: 10.1002/jnr.22484

Fig. 1. Laminin potentiates IGF-mediated effects on oligodendrocyte differentiation.

Fig. 1

Oligodendrocytes were differentiated on PDL or laminin substrates for 3 days in the presence or absence of 50 ng/ml IGF-1. (A) Differentiated oligodendrocytes were evaluated using CNP immunocytochemistry. Representative micrographs of CNP immunoreactivity (red) and DAPI nuclear stain (blue) are shown. Scale bar, 50 μM. (B) Differentiated oligodendrocytes were evaluated using MBP immunocytochemistry. Representative micrographs of MBP immunoreactivity (green) and DAPI nuclear stain (blue) are shown. Scale bar, 50 μM. (C) Bars represent the mean (± sem) relative change in MBP(+) oligodendrocyte cell area after differentiation on PDL or laminin (Lm), in the presence or absence of 50 ng/ml IGF-1. Mean areas are normalized to mean area of control cells on PDL (*p<0.05, n=3).