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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Curr Opin Chem Biol. 2010 Jul 30;14(5):616–622. doi: 10.1016/j.cbpa.2010.06.186

Figure 1.

Figure 1

NPs and biomolecular interfaces. a) NPs, biomolecules, NP-biomolecule conjugates, and biological environments are much more complex (right) than typically depicted (left). (i) from [13] ; (ii) PDB ID 1YCC from [58], (iv) Illustration by David S. Goodsell, the Scripps Research Institute. b) Interface effects can diminish the biological function of NP-biomolecule conjugates (upper) and NPs used for therapy in cells and biological fluid, leading to undesirable and unpredictable side effects.