Fig. 1.

Upper panel: Effects of cocaine and D-84 dose (mg/kg) on the percentage of cocaine-lever responses in rats trained to discriminate 10 mg/kg cocaine. “V”=20% w/v cyclodextrin vehicle; ”S”=saline; filled circles=cocaine; filled squares=D-84. Each symbol represents a mean of six rats, except N=4 and 2 at 30 and 42 mg/kg, respectively, because some rats failed to meet minimum response rate criteria (see text) and their data were not included for %CLR expressions but were included for expressions of response rate. Bars represent ±S.E.M.. When ratios of N are provided at a dose the denominator indicates total rats tested at that dose, and the numerator indicates the number meeting response rate criteria. If a rat failed to meet response rate criteria at a lower dose, it was not tested at higher doses (e.g., only four rats were tested at 42 mg/kg because two had not met response rate criteria at 30 mg/kg).

Bottom panel: Mean numbers of total lever presses per sec. Each symbol represents a mean of six rats except N=4 at 42 mg/kg because two rats failed to meet response criteria at the preceding, lower dose (i.e., at 30 mg/kg) and were not tested at higher doses (see text). Other details as described for the upper panel.