Upper panel: Mean infusions of cocaine doses of 0.01, 0.1, 0.5 and 1 mg/kg/infusion as a function of D-84 pretreatment dose. Bars through the data points indicate the S.E.M. N=5 at 9.6 and 17.1 mg/kg D-84; N=6 at 30.4 mg/kg D-84.
Bottom panel: Cocaine intake (mg/kg/2-h session) obtained as a function of D-84 pretreatment dose. * = P< 0.05, **= P< 0.01, ***= P< 0.002 as compared to vehicle pre-treatment. Other details as in the upper panel.