Table 2.
Test 1 results
| CL | V | ||||||
|---|---|---|---|---|---|---|---|
| GV (%) | E 2 (%) | P(GV > E 2)a | GV (%) | E 2 (%) | P(GV > E 2)a | ||
| Outliers | 2.60 | 6.65 | <0.0001 | Outliers | 2.25 | 6.10 | <0.0001 |
| CV | 9.80 | 61.4 | <0.0001 | CV | 11.3 | 320 | <0.0001 |
Median percentage outliers (±3 interquartile ranges) and coefficients of variation (CVs) of plasma clearance (CL) and volume of distribution (V) from GV and E 2 SET fit-parameters for 1000 bootstrap realizations each for 46 patient studies (46,000 simulations)
The right most column shows the vanishingly small probabilities for CL and V that E 2 SETs have fewer outliers (or smaller CVs) than GV as determined by the Wilcoxon signed-ranks sum test