Skip to main content
. 2010 Sep 24;37(5):435–474. doi: 10.1007/s10928-010-9167-z

Table 6.

Test 4 results from extrapolation testing using the Wilcoxon signed-ranks sum test.a Over- or underestimation of extrapolated ln C(t) values for five fit methods. Note that Tk-GV extrapolated best

Fit type Wilcoxon test probability Median differencea Median difference 95% confidence intervals
E 2 0.0046 −0.0383 −0.0634 to −0.0140
E 2 b 0.0071 −0.0373 −0.0629 to −0.0118
GV 0.2446 0.0131 −0.0088 to 0.0491
GVc 0.7638 0.0039 −0.0158 to 0.0334
Tk-GV 0.9087 −0.0011 −0.0192 to 0.0217

aThis does not always agree in sign with a sign difference

bConstrained fit: Inline graphic, Inline graphic for Inline graphic

cConstrained fit: Inline graphic for Inline graphic