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. 2010 Sep 24;37(5):435–474. doi: 10.1007/s10928-010-9167-z

Table 7.

Test 4 difference between CL (ml/min) values without the last sample (m−1) and with all m samples for the Tk-GV and constrained E 2 SET models

CL m−1 CL m ΔCL Inline graphic CV
Tk-GV
 Mean 74.99 74.47 0.52 3.90 8.96%
 Median 74.73 74.28 0.46 2.65 5.05%
E 2
 Mean 81.95 80.95 1.00 6.10 11.23%
 Median 82.78 78.76 4.02 3.58 5.73%

ΔCL is the difference between the CL values calculated using m  1 and m samples. S CL is the standard deviation between each calculation, and CV is the coefficient of variation from using m  1 and m samples. Note that Inline graphic is implausible, (P = 0.02, Wilcoxon, 1-tailed)