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. 2010 Sep 24;37(5):435–474. doi: 10.1007/s10928-010-9167-z

Table 8.

Comparison of Inline graphic, Inline graphic and Inline graphic plasma clearances from three sources. Note that Inline graphic is more accurate than Inline graphic, yet is within the CI for constant infusion and 24 h AUC

Units: ml/min/1.73 m2 Percent
Source: Florijn et al. This paper Moore et al. This paper
E 2 approximation: 5 min injectiona Constrainedb 4 h AUCc Constrained
Inline graphic method: Constant infusion Tk-GV 24 h AUC Tk-GV
95% CI 95% CI
Inline graphic 5.1 6.1 4.7 to 7.6 10.0 10.6  8.6 to 12.7
Inline graphic 8.3 ~7.3  7.6 ~7.0 
Inline graphic 13.4 17.6

aInulin, Inline graphic

b 99mTc-DTPA, Inline graphic with constraints Inline graphic and Inline graphic

c 51Cr-EDTA, from numerical integration of Inline graphic, then mono-exponential extrapolation