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. 2010 May 7;192(21):5755–5766. doi: 10.1128/JB.00135-10

FIG. 6.

FIG. 6.

Diagram of the steps of the BER pathway of A. fulgidus for repair of uracil in DNA. The residues removed and the results of replacement are indicated by red and blue, respectively; proteins with verified biochemical activity (e.g., Afung and Afogg; however, whether Afxth contains 3′-phosphodiesterase activity and whether AfpolB1 is able to fill in one-nucleotide gaps have not been verified [6, 52]) are indicated by black type; putative proteins based on genomic sequences (ORFs) are indicated by white type. The genes encoding the proteins are as follows (Swiss-Prot/TrEMBL accession numbers are indicated in parentheses): Afogg, AF0371 (O29876); Afnth, AF1692 (O28581); Afxth, AF0580 (O29675); AfpolB1, AF0497 (O29753); AfpolB2, AF0693m; Aflig1, AF0623 (O29632); and Aflig2, AF1725 (O28549). dR, deoxyribose residue; dR′, modified deoxyribose residue (i.e., α,β-unsaturated aldehyde); dRP, deoxyribose phosphate; P, phosphate group. A solid arrow indicates a step confirmed experimentally; a dashed arrow indicates a step not demonstrated experimentally yet.