TABLE 4.
Gene clusters shared by the highly virulent serovars in A. pleuropneumoniae
| Cluster | Distributed serotypes | Annotation of predicted protein product |
|---|---|---|
| APO_1721 | 1, 2, 5b, 6, 7, 9, 10, 11, 12, 13, 4 | SNF2-related protein |
| APO_1723 | 1, 2, 7, 12, 13, 6, 5b, 9, 11, 4, 10 | Truncated transferrin-binding protein 1 |
| APO_1726 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Homoserine dehydrogenase |
| APO_1729 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | GTP pyrophosphokinase |
| APO_1730 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Elongation factor G |
| APO_1746 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Exodeoxyribonuclease 7 large subunit |
| APO_1764 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Malate dehydrogenase (oxaloacetate-decarboxylating) [NADP(+)], phosphate acetyltransferase |
| APO_1767 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Molybdopterin biosynthesis protein moeA |
| APO_1779 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Glycerophosphoryl diester phosphodiesterase |
| APO_1797 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Uncharacterized periplasmic iron-binding protein |
| APO_1806 | 1, 2, 4, 6, 7, 9, 10, 11, 12, 13, 5b | DacC protein |
| APO_1811 | 1, 2, 4, 5b, 6, 7, 10, 11, 12, 13, 9 | Carbonic anhydrase |
| APO_1812 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | tRNA [adenine-N(6)-]-methyltransferase |
| APO_1817 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | FKBP-type peptidyl-prolyl cis-trans isomerase 1 |
| APO_1825 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | 50S ribosomal protein L10 |
| APO_1852 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 12, 13 | Hypothetical protein |
| APO_1866 | 1, 7, 9, 11, 13, 2, 4, 5b, 12, 6 | Acetyltransferase |
| APO_1874 | 1, 2, 5b, 6, 7, 9, 10, 11, 13, 12 | Threonine efflux protein |
| APO_1878 | 1, 2, 4, 5b, 7, 9, 10, 11, 12, 13 | Uncharacterized protein |
| APO_1879 | 1, 2, 5b, 6, 7, 9, 10, 11, 12, 13 | Endoribonuclease L-PSP |
| APO_1881 | 1, 2, 4, 5b, 6, 7, 9, 10, 11, 13 | Putative uncharacterized protein |
| APO_1895 | 1, 9, 11, 4, 5b, 7, 10, 12, 13 | ATP-dependent RNA helicase RhlB |
| APO_1896 | 1, 4, 5b, 7, 9, 11, 12, 13, 10 | Flp operon protein C, RcpC |
| APO_1897 | 1, 2, 4, 5b, 7, 9, 11, 12, 13 | Probable ABC transporter permease protein |
| APO_1901 | 7, 12, 1, 2, 5b, 6, 9, 11, 13 | Putative uncharacterized protein |
| APO_1905 | 1, 2, 5b, 6, 7, 9, 11, 12, 13 | Putative uncharacterized protein |
| APO_1916 | 1, 5b, 9, 11, 12, 6, 7, 13 | Hemolysin activation/secretion protein |
| APO_1920 | 1, 2, 5b, 7, 9, 11, 12, 13 | Transposase IS200-like protein |
| APO_1927 | 1, 2, 4, 5b, 9, 10, 11, 12 | Hypothetical protein |
| APO_1961 | 10, 5b, 7, 1, 9, 11 | Phage terminase large subunit |
| APO_1967 | 10, 5b, 7, 1, 9, 11 | Bacteriophage capsid protein |
| APO_1968 | 1, 9, 11, 12, 5b, 10 | Undecaprenyl-phosphate galactose phosphotransferase, WbaP |
| APO_1973 | 12, 10, 1, 5b, 9, 11 | Hypothetical protein |
| APO_1987 | 2, 5b, 6, 1, 9, 11 | Outer membrane receptor proteins, mostly Fe transport |
| APO_1988 | 10, 1, 5b, 7, 9, 11 | Uncharacterized protein |
| APO_2004 | 1, 5b, 9, 10, 11 | RTX-I toxin determinant A from serotypes 5/10, ApxIA |
| APO_2006 | 7, 1, 9, 11, 5b | ATP-dependent Clp protease proteolytic subunit |
| APO_2010 | 1, 5b, 9, 10, 11 | Putative uncharacterized protein |
| APO_2012 | 1, 5b, 6, 9, 11 | Predicted phage integrase family protein |
| APO_2016 | 1, 9, 11, 5b, 10 | ABC transporter ATP binding subunit, Wzm |
| APO_2018 | 1, 5b, 9, 10, 11 | Possible bacteriophage antirepressor |
| APO_2024 | 1, 5b, 7, 9, 11 | Putative phage tail component |
| APO_2025 | 1, 5b, 9, 11, 10 | Possible DNA methylase |
| APO_2026 | 5b, 10, 1, 9, 11 | Hemolysin-activating lysine-acyltransferase HlyC, ApxIC |
| APO_2027 | 5b, 1, 9, 11, 12 | Putative uncharacterized protein |
| APO_2030 | 5b, 10, 1, 9, 11 | Putative uncharacterized protein |
| APO_2031 | 1, 5b, 7, 9, 11 | Possible bacteriophage tail protein |
| APO_2033 | 1, 5b, 9, 10, 11 | Hypothetical protein |
| APO_2038 | 1, 5b, 9, 10, 11 | Hypothetical protein |
| APO_2039 | 10, 1, 5b, 9, 11 | Hypothetical protein |
| APO_2040 | 1, 9, 11, 5b, 10 | Hypothetical protein |
| APO_2043 | 1, 2, 5b, 9, 11 | Hypothetical protein |
| APO_2085 | 1, 5b, 9, 11 | Site-specific DNA methylase |
| APO_2140 | 5b, 9, 11, 1 | Hypothetical protein |