Behavioral effects of unilateral 6-OHDA lesion and chronic L-DOPA treatment on depression-like behaviors in the modified forced swim test. (A) Climbing, (B) swimming, and (C) immobility behaviors for the first 5 min of day 1 of exposure (white bars) and first 5 min of day 2 of exposure (black bars) are shown for Sham-VEH, Sham-LD, Lesion-VEH, and Lesion-LD groups (n=5/group). Two-way ANOVAs revealed significant main effects of day on climbing and immobility. A significant lesion by day interaction was also found for climbing (*p<0.05).