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. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Behav Pharmacol. 2010 Oct;21(7):627–637. doi: 10.1097/FBP.0b013e32833e7e80

Neurochemical effects of unilateral 6-OHDA lesion and chronic L-DOPA treatment as determined by HPLC-ED. Monoamine levels within the striatum (STR), prefrontal cortex (PFC), hippocampus (HPC), and amygdala (AMG) are shown for (A) DA, (B) DOPAC, (C) NE, (D) 5-HT, and (E) 5-HIAA. Interactions and main effects of lesion ( p<0.05) and treatment ( p<0.05) were determined via two-way ANOVA. LSD post-hoc comparisons demonstrated significant differences between Sham-VEH (* p<0.05), Sham-LD (+ p<0.05), and Lesion-VEH (# p<0.05).

Inline graphic — Neurochemical effects of unilateral 6-OHDA lesion and chronic L-DOPA treatment as determined by HPLC-ED. Monoamine levels within the striatum (STR), prefrontal cortex (PFC), hippocampus (HPC), and amygdala (AMG) are shown for (A) DA, (B) DOPAC, (C) NE, (D) 5-HT, and (E) 5-HIAA. Interactions and main effects of lesion ( p<0.05) and treatment ( p<0.05) were determined via two-way ANOVA. LSD post-hoc comparisons demonstrated significant differences between Sham-VEH (* p<0.05), Sham-LD (+ p<0.05), and Lesion-VEH (# p<0.05).