Figure 1. CCl4-induced hepatic injury.
Male C57BL/6 mice were fed control (CD) or western (WD) diet for 3 weeks, treated with vehicle or CCl4 (0.1 μl/g) and sacrificed after up to 7 days. Photomicrographs are liver sections representative of at least 4 observations/group stained with hematoxylin and eosin. Original magnification = 32x. Centrilobular necroinflammation peaked at day 2 in mice fed CD and was nearly resolved by day 7. Although initial injury was similar among the dietary groups, feeding WD enhanced injury at days 2–7. Arrows denote borders of necrotic areas.