Table 1.

Non-compartmental plasma and CSF PK parameters of ABT-888 after a single oral 5 mg/kg dose in non-human primates

Animal	$C_{max}^{\text{P}}(\mu \text{M})$	${\text{AUC}}_{0-\infty }^{\text{P}}(\mu \text{M}\text{h})$	ClTB/F (L/h/kg)	Vdss/F (L/kg)	$t_{1/2}^{\text{P}}(\text{h})$	$C_{max}^{\text{CSF}}(\mu \text{M})$	${\text{AUC}}_{0-\infty }^{\text{CSF}}(\mu \text{M}\text{h})$	CSF penetration (%)
1	0.45	2.4	8.5	46	3.7	0.15	1.4	56
2	0.60	3.0	6.7	38	3.1	0.16	2.0	64
3	0.81	5.6	3.7	29	3.4	0.37	2.8	51
Mean	0.62	3.7	6.3	38	3.4	0.23	2.1	57
SD	0.18	1.7	2.4	8	0.6	0.12	0.8	7

All parameters reported to two significant digits

$C_{\mathit{max}}^P$ maximum plasma concentration, ${\mathit{AUC}}_{0-\infty }^P$ area under the curve extrapolated to infinity, Cl_TB/F apparent clearance, Vd_ss/F apparent volume of distribution, $t_{1/2}^P$ plasma half-life, $C_{\mathit{max}}^{\mathit{CSF}}$ maximum CSF concentration, ${\mathit{AUC}}_{0-\infty }^{\mathit{CSF}}$ area under the curve extrapolated to infinity, CSF penetration ${\text{AUC}}_{0-\infty }^{\text{CSF}}/{\text{AUC}}_{0-\infty }^{\text{P}}\times 100$