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. Author manuscript; available in PMC: 2010 Oct 13.
Published in final edited form as: Xenobiotica. 2009 Mar;39(3):205–217. doi: 10.1080/00498250802613620

Table 3.

Intrinsic metabolic activities of DMSO-treated Huh7 cells.

Differentiated Huh7 Human hepatocytes References
Midazolam
1-Hydroxymidazolam production rate (pmol min−1 per 106 cells) 0.87 10–28 Kanebratt and Andersson (2008), Ledirac et al. (2000),
Intrinsic clearance (μl min−1 per 106 cells) 0.00059 0.0015–0.04 Hallifax et al. (2005), Li et al. (1997)
Lamotrigine
Intrinsic clearance (μl min−1 per 106 cells) 0.00099 0.11 (liver microsome)a Rowland et al. (2006)
Diclofenac
4-Hydroxydiclofenac production rate (pmol min−1 per 106 cells) 0.189 300 Hewes et al. (2006)
a

Based on previous reports indicating that 1 g of liver tissue is equivalent to 40 mg microsomal proteins (Hakooz et al. 2006) and 108 hepatocytes (Wilson et al. 2003).