Table 3.

Bivariate and multivariate associations of specific depressive symptoms (entered as continuous variables) with cardiovascular events.

	Hazard ratio* (95% CI)	P-value*	Hazard ratio† (95% CI)	P-value†
Somatic symptoms
Fatigue	1.21 (1.10–1.33)	0.0001	1.15 (1.04–1.27)	0.007
Appetite problems	1.27 (1.15–1.41)	<0.0001	1.17 (1.06–1.30)	0.003
Psychomotor agitation/retardation	1.14 (1.00–1.29)	0.05	1.12 (0.98–1.28)	0.10
Sleeping difficulties	1.11 (1.01–1.21)	0.03	1.07 (0.98–1.18)	0.14
Cognitive symptoms
Lack of interest	1.11 (0.99–1.25)	0.07	1.04 (0.93–1.17)	0.48
Depressed mood	1.19 (1.05–1.33)	0.005	1.13 (1.00–1.28)	0.05
Worthlessness	1.11 (0.98–1.26)	0.09	1.10 (0.97–1.25)	0.15
Concentration problems	1.02 (0.90–1.15)	0.75	1.00 (0.88–1.13)	0.94
Suicidal ideation	1.25 (1.03–1.53)	0.02	1.14 (0.94–1.39)	0.19

^*Adjusted for age and gender

^†Adjusted for age, gender, diabetes mellitus, history of MI, history of stroke, history of heart failure, left ventricular ejection fraction, body mass index, smoking aspirin, beta blocker, statin, and renin-angiotensin system inhibitor