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Calcineurin inhibition prevents H-IH-induced NFAT activation. A and B: luciferase activity in aorta and mesenteric arteries isolated from air and H-IH-exposed 9×NFAT-luc mice treated with cyclosporin A (CsA, 25 mg·kg–1·day–1) or vehicle (V) for 3 days and exposed to H-IH for the last 2 days of CsA treatment. Luciferase activity was normalized by micrograms of total protein. Values are means ± SE (n = 5). *P < 0.01 vs. air; #P < 0.01 vs. CsA (ANOVA and Tukey's test).
