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. Author manuscript; available in PMC: 2011 Mar 23.

Published in final edited form as: Circulation. 2010 Mar 8;121(11):1313–1321. doi: 10.1161/CIRCULATIONAHA.109.887687

Some modifier loci may contribute to the development of both ASD and VSD. (A) ASD and VSD co-occur in the F2 intercrosses and C57Bl/6 backcross of the C57Bl/6 X A/J F1 more often than expected by the null hypothesis of complete independence between the defects. (B) The co-incidence rates are subdivided by VSD types in the two intercross populations, which have sufficiently large sample sizes for statistical comparison.

Some modifier loci may contribute to the development of both ASD and VSD. (A) ASD and VSD co-occur in the F2 intercrosses and C57Bl/6 backcross of the C57Bl/6 X A/J F1 more often than expected by the null hypothesis of complete independence between the defects. (B) The co-incidence rates are subdivided by VSD types in the two intercross populations, which have sufficiently large sample sizes for statistical comparison.