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. 2010 Jun 25;116(14):2494–2503. doi: 10.1182/blood-2010-03-277103

Figure 2.

Figure 2

IL-15Rα+ DCs partially recover peripheral iNKT cells. (A) Representative flow cytometric plots of CD1d tetramer+ CD3+ cells in the thymus, liver, and spleen of IL-15Rα−/− (left column), CD11c/IL-15Rα Tg (middle column), and WT (right column) mice. Plots are representative of 3 independent experiments. (B) Absolute numbers of iNKT cells as detected by CD1d tetramer were calculated for each group of mice, IL-15Rα−/− (■), CD11c/IL-15Rα Tg (Inline graphic), and WT (□), in the respective tissues. Error bars represent SEM, and the numbers above bars represent the percentage of WT levels. *P ≤ .05. Data are the average of 3 independent experiments; n = 6/group. Tg and WT iNKT cell numbers were statistically compared against total iNKT from IL-15Rα−/− mice. (C) Absolute numbers of iNKT subsets as determined by CD44 and NK1.1 expression in the indicated mice.