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Model of E2F2-mediated regulation of the Ahr pathway. E2F2 represses the expression of Ahr pathway components Ahr, Aip and Arnt. In the absence of E2F2, higher levels of Ahr pathway gene products accumulate in the cytosol. In response to xenobiotics, E2F2-deficient cells exhibit greater Ahr-dependent transcriptional activation, resulting in increased apoptosis.
