Fig. 2.

Distinct categories of intrinsically disordered structures adopted by FG nups. Stokes radii values obtained for the purified FG domains (Table I) were divided by the values predicted for each nup based on its mass assuming a relaxed coil configuration (y axis). The AA composition of each domain was expressed as the percent content of charged AAs (i.e. DEKR) divided by the percent content of hydrophobic AAs (i.e. AILFWV) (x axis). Gray boxes highlight the two main categories of intrinsically disordered structures. Nup domains with a low or high charge content are highlighted in blue or red boxes, respectively. The green line highlights the correlation between category of intrinsically disordered structure and charged-to-hydrophobic AA ratio.