Reduced protein levels of CaM kinases proteins in CBP cKO mice. Cortical lysates were used to conduct immunoblotting to determine protein levels. Protein levels were normalized to β-actin. There are significant reductions on protein levels for CaMK1γ, CaMKIIβ, CaMKIIγ, CaMKIIδ, CaMKKα, and CaMKKβ in CBP cKO mice (*p < 0.05; ***p < 0.005; ****p < 0.001; control, n = 5–9; cKO, n = 8–9).