Fig. 1.

An arginine responsible for FPP binding in the activated group. A close up view of the docked FPP-ERα complex showing a salt bridge between the R394 from the ERα LBP and the negatively charged pyrophosphate group of FPP. FPP's hydrocarbon backbone and pyrophosphate group are represented in yellow–grey and red–yellow, respectively. ERα backbone is depicted as a ribbon colored from N- to C-termini in a gradient from blue to red. [Images created using ICM graphics tools.]