Figure 3.

Effect of trimetazidine(TMZ) treatment on serum and intramyocardial lipid accumulation. (A) Serum triglyceride levels were reduced in TMZ-treated mice compared to diabetic db/db mice. ^bP<0.05 compared to C57 group; ^eP<0.05 compared to db/db group. (B) Photomicrographs showing the histologic appearance of ventricular tissue from C57, diabetic (db/db), low-dose trimetazidine-treated (TMZ-low), and high-dose trimetazidine-treated (TMZ-high) mouse heart at low (upper panels) and high (lower panels) magnification. Frozen tissue sections were stained with oil red O. Red droplets indicate neutral lipids. Oil red O staining quantification is expressed as a percentage of total area. ^bP<0.05 compared to C57 group. ^eP<0.05 compared to db/db group.