Table 2.
Genome-Wide Association Studies for Breast, Prostate and Colorectal Cancers
| Locus | Implicated Gene | SNP | Per Allele OR Ranges* | Reference |
|---|---|---|---|---|
| Breast | ||||
| 1p11.2 | Pericentric | rs11249433 | 1.16 | 54 |
| 2q35 | Intergenic | rs13387042 | 1.2-1.25 | 54,55 |
| 3p24.1 | SLC4A7 | rs4973768 | 1.11 | 56 |
| 5p12 | Intergenic (MRPS30) | rs4415084 | 1.16-1.19 | 57 |
| rs10941679 | ||||
| 5q11.2 | MAP3K1, MIER3, C5orf35 | rs889312 | 1.13 | 45 |
| 6q22.33 | ECHDC1, RNF146 | rs2180341 | 1.41 | 58 |
| 6q25.1 | ESR1 | rs2046210 | 1.29 | 59 |
| 8q24 | Intergenic | rs13281615 | 1.08 | 45 |
| 10q26 | FGFR2 | rs2981582 | 1.20-1.29 | 45 |
| rs1219648 | 57,60 | |||
| rs1078806 | 58 | |||
| 11p15.5 | LSP1 | rs3817198 | 1.07 | 45 |
| 14q24.1 | RAD51L1 | rs999737 | 1.06 | 54 |
| 16q12 | TNRC9 (TOX3), LOC643714 | rs3803662 | 1.16-1.28 | 45,54,55 |
| 17q23 | STXBP4 | rs6504950 | 1.05 | 56 |
| Prostate | ||||
| 2p15 | EHBP1 | rs721048 | 1.15 | 61 |
| 2p21 | THADA | rs1465618 | 1.08 | 62 |
| 2q31 | ITGA6 | rs12621278 | 1.33 | 62 |
| 3p12 | Intergenic | rs2660753 | 1.18 | 64 |
| 3q21 | Intergenic | rs10934853 | 1.12 | 63 |
| 4q22 | PDLIM5 | rs17021918 | 1.11 | 62 |
| rs12500426 | 1.08 | |||
| 4q24 | TET2 | rs7679673 | 1.10 | 62 |
| 6q25 | SLC22A3 | rs9364554 | 1.17 | 64 |
| 7p15 | Intergenic | rs12155172 | 1.05 | 62 |
| 7p15.2-15.1 | JAZF1 | rs10486567 | 1.12-1.35 | 65 |
| 7q21.3 | LMTK2 | rs6465657 | 1.12 | 64 |
| 8p21 | NKX3-1 | rs2928679 | 1.05 | 62 |
| rs1512268 | 1.18 | |||
| 8q24 | Intergenic | HapC 14 SNPs | 2.10 | 66 |
| rs16901979 | 1.79-1.80 | 63,66 | ||
| DG8S737 | 1.64 | 67 | ||
| rs1447295 | 1.36-1.60 | 63,66–69 | ||
| rs1016343 | 1.37 | 64 | ||
| rs6983267 | 1.26-1.42 | 64,65,69 | ||
| rs4242382 | 1.41-1.87 | 64,65 | ||
| rs1006908 | 1.15 | 70 | ||
| rs620861 | 1.17 | 71 | ||
| rs16902094 | 1.14 | 63 | ||
| 10q11.2 | MSMB | rs10993994 | 1.16-1.25 | 64,65 |
| 10q26.13 | CTBP2 | rs4962416 | 1.17-1.20 | 65 |
| 11p15 | IGF2, IGF2AS, INS, TH | rs7127900 | 1.22 | 62 |
| 11q13.2 | Intergenic | rs10896449 | 1.10-1.28 | 65 |
| rs7931342 | 1.19 | 64 | ||
| rs11228565 | 1.23 | 63 | ||
| 17q12 | TCF2 (HNF1B) | rs4430796 | 1.18-1.38 | 63,65,72 |
| rs7501939 | 1.41 | 64 | ||
| 17q24.3 | Intergenic | rs1859962 | 1.20-1.26 | 64,72 |
| 19q13.2 | PPP1R14A | rs8102476 | 1.12 | 63 |
| 19q13.41 | KLK2, KLK3 | rs2735839 | 1.20 | 64 |
| 22q13 | TTLL1, BIK, MCAT, PACSIN2 | rs5759167 | 1.20 | 62 |
| 22q13 | TNRC6B | rs9623117 | 1.18 | 73 |
| Xp11.23-p11.22 | NUDT10, NUDT11, | rs5945619 | 1.19 | 64 |
| LOC340602, GSPT2, MAGED1 | rs5945572 | 1.23 | 61 | |
| Colorectal | ||||
| 8q23.3 | EIF3H | rs16892766 | 1.25 | 74 |
| 8q24.21 | LOC727677, POU5F1P1 | rs10505477 | 1.17 | 75 |
| Intergenic | rs6983267 | 1.17-1.27 | 74,76 | |
| rs7014346 | 1.19 | 78 | ||
| 10p14 | Intergenic | rs10795668 | 1.11 | 74 |
| 11q23 | Intergenic | rs3802842 | 1.12 | 78 |
| 14q22-q23 | BMP4 | rs4444235 | 1.11 | 79 |
| 15q13 | Intergenic | rs4779584 | 1.23-1.26 | 74,80 |
| GREM1 | rs10318 | 1.19 | 80 | |
| 16q22.11 | CDH1 | rs9929218 | 1.10 | 79 |
| 18q21.1 | SMAD7 | rs4939827 | 1.16-1.20 | 78,81 |
| 19q13.11 | RHPN2 | rs10411210 | 1.15 | 79 |
| 20p12.3 | Intergenic | rs961253 | 1.12 | 79 |
Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio.
*
ORs < 1 in the original publication have been converted to ORs > 1 for the alternate allele.