Table 3.
Genome-Wide Association Studies for Other Cancers
| Locus (entrez gene) | Implicated Gene | SNP | Per Allele OR Ranges* | Reference |
|---|---|---|---|---|
| Lung | ||||
| 5pter-p15.33 | CLPTM1L, TERT | rs401681 | 1.16 | 104 |
| rs402710 | 1.18 | 105 | ||
| rs2736100 | 1.14 | 105 | ||
| 1.23 (adenocarcinoma) | 106 | |||
| 5p15.33 | rs4975616 | 1.16 | 107 | |
| 6p21.33-p21.3 | BAT3, MSH5 | rs3117582 | 1.24 | 104,107 |
| 15q24-q25 | CHRNA3, CHRNA5, CHRNB4, | rs8034191 | 1.30-1.38 | 108–110 |
| PSMA4, LOC123688 | ||||
| rs1051730 | 1.31-1.35 | 105,108,110 | ||
| rs8042374 | 1.33, NR | 104,107 | ||
| 15q25.1 | CHRNA3 | rs938682 | 1.33 | 107 |
| rs12914385 | 1.29 | 107 | ||
| BCC and CM | ||||
| 1p36.13 | PADI4, PADI6, RCC2, AHRGEF10L | rs7538876 | 1.28 BCC | 111 |
| 1q42.11-q42.3 | RHOU | rs801114 | 1.28 BCC | 111 |
| 7q32 | KLF14 | rs157935 | 1.23 BCC | 112 |
| 9p21 | MTAP, CDKN2A | rs7023329 | 1.18 CM | 113 |
| 9p21 | CDKN2A, CDKN2B | rs2151280 | 1.19 BCC | 112 |
| 9p23 | TYRP1 | rs1408799 | 1.15 CM | 114 |
| 11q14-q21 | TYR | rs1126809 | 1.21 CM | 114 |
| 1.14 BCC | ||||
| rs1393350 | 1.29 CM | 113 | ||
| 12q12-q13 | KRT5 | rs11170164 | 1.35 BCC | 112 |
| 16q24 | MC1R | rs258322 | 1.67 CM | 113 |
| 20q11.2-q12 | ASIP | Hap rs1015362G and rs4911414T | 1.45 CM | 114 |
| 1.35 BCC | ||||
| 20q11.22 | CDC91L1 (PIGU) | rs910873 and rs1885120 | 1.75 CM | 115 |
| Urinary bladder | ||||
| 3q28 | TP63 | rs710521 | 1.19 | 116 |
| 8q24.21 | MYC, BC042052 | rs9642880 | 1.22 | 116 |
| 8q24.2 | PSCA | rs2294008 | 1.15 | 117 |
| Neuroblastoma | ||||
| 2q35 | BARD1 | rs3768716 | 1.68 | 118 |
| rs6435862 | 1.68 | |||
| 6p22.3 | FLJ22536, FLJ44180 | rs4712653 | 1.35 | 119 |
| rs9295536 | 1.32 | |||
| rs6939340 | 1.37 | |||
| Glioma | ||||
| 5p15.33 | TERT | rs2736100 | 1.27 | 120 |
| 8q24.21 | CCDC26 | rs4295627 | 1.36 | 120 |
| 9p21.3 | CDKN2B | rs1412829 | 1.42 | 121 |
| rs4977756 | 1.24 | 120 | ||
| 11q23.3 | PHLDB1 | rs498872 | 1.18 | 120 |
| 20q13.33 | RTEL1 | rs6010620 | 1.51 | 121 |
| 1.28 | 120 | |||
| Acute lymphoblastic leukemia (childhood) | ||||
| 7p12.2 | IKZF1 | rs4132601 | 1.69 | 122 |
| 10q21.2 | ARID5B | rs10994982 | 1.62 | 123 |
| Maps to 10q11.22 by HGNC | rs10821936 | 1.91 | 123 | |
| rs7089424 | 1.65 | 122 | ||
| 14q11.2 | CEBPE | rs2239633 | 1.34 | 122 |
| Chronic lymphocytic leukemia | ||||
| 2q13 | ACOXL, BCL2L11 | rs17483466 | 1.39 | 124 |
| 2q37.1 | SP140 | rs13397985 | 1.41 | 124 |
| 2q37.3 | FARP2 | rs757978 | 1.39 | 125 |
| 6p25-p23 | IRF4 | rs872071 | 1.54 | 124 |
| 8q24.21 | Intergenic | rs2456449 | 1.26 | 125 |
| 11q24.1 | GRAMD1B | rs735665 | 1.45 | 124 |
| 15q21.3 | NEDD4, RFX7 | rs7169431 | 1.36 | 125 |
| 15q23 | Intergenic | rs7176508 | 1.37 | 124 |
| 16q24.1 | IRF8 | rs305061 | 1.22 | 125 |
| 19q13.2-q13.3 | PRKD2, STRN4 | rs11083846 | 1.35 | 124 |
| Follicular lymphoma | ||||
| 6p21.33 | STG, PSORS1 | rs6457327 | 1.69 | 126 |
| Thyroid (papillary and follicular) | ||||
| 9q22.33 | Intergenic | rs965513 | 1.75 | 127 |
| 14q13.3 | Intergenic | rs944289 | 1.37 | 127 |
| Myeloproliferative neoplasms | ||||
| 9p24.1 | JAK2 | rs10974944 | 3.10 | 52 |
| Testicular germ cell cancer | ||||
| 4q24 | Intergenic | rs4699052 | 1.21 | 53 |
| 5q31.3 | SPRY4 | rs4324715 | 1.37 | 51 |
| rs4624820 | 1.37 | 53 | ||
| rs6897876 | 1.39 | 51 | ||
| 6p21.3 | BAK1 | rs210138 | 1.50 | 53 |
| 12q22 | KITLG | rs995030 | 2.55 | 53 |
| rs3782179 | 3.08 | 51 | ||
| rs4474514 | 3.07 | 51 | ||
| rs1508595 | 2.69 | 53 | ||
| Pancreatic | ||||
| 1q32.1 | NR5A2 | rs3790844 | 1.30 | 127a |
| 5p15.33 | TERT-CLPTM1L | rs401681 | 1.19 | 127a |
| 9q34 | ABO | rs505922 | 1.20 | 128 |
| 13q22.1 | Intergenic | rs9543325 | 1.26 | 127a |
| Ovarian | ||||
| 9p22 | BNC2, CNTLN, LOC648570 | rs3814113 | 1.22 | 129 |
| Gastric (diffuse) | ||||
| 8q24.3 | PSCA | rs2976392 | 1.62 (Japan) | 130 |
| 1.90 (Korea) | ||||
| Esophageal (squamous cell) | ||||
| 4q21-23 | ADH1B | rs1229984 | 1.79 | 131 |
| 12q24 | ALDH2 | rs671 | 1.67 | 131 |
| Single locus 5p15.33 Multiple cancers | TERT-CLPTM1L | rs401681 | 132 | |
| Prostate | 1.07 | |||
| Lung | 1.15 | |||
| BCC | 1.25 | |||
| Urinary bladder | 1.12 | |||
| Cervical | 1.31 |
Abbreviations: OR, odds ratio; NR, not reported; BCC, basal cell carcinoma; CM, cutaneous melanoma.
*
ORs < 1 in the original publications have been converted to ORs > 1 for the alternate allele.