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. 2010 Aug 5;2(8):527–534. doi: 10.18632/aging.100184

Figure 2.

Figure 2.

A FXR/SIRT1 positive-feedback regulatory loop. The expression and activity of FXR and SIRT1 are mutually and coordinately regulated. SIRT1 positively auto-regulates its own expression by inhibiting miR-34a via deacetylation (as indicated by dotted circles) of p53 and histones at the miR-34a promoter (short loop) and by increasing transactivation potential of FXR via deacetylating the FXR (long loop). SIRT1 also increases FXR expression and activity via deacetylation of PGC-1α. FXR in turn positively regulates hepatic SIRT1 expression by inhibiting miR-34a which targets SIRT1.