Table 2.

Effect of NAc DA depletions on tissue concentrations of DA and noradrenaline in the NAc and dorsolateral striatum taken from each hemisphere

Location	Sham lesion (n = 6)	Vehicle infusion (n = 6)	6-OHDA NAc infusion (n = 10)
NAc
DA concentration (pmol/tissue sample)
Left hemisphere	11.36 ± 1.48	13.40 ± 4.08	1.04 ± 0.28
Right hemisphere	10.92 ± 1.68	14.72 ± 3.08	1.44 ± 0.28
Average	11.16 ± 1.48	14.08 ± 3.32	1.24 ± 0.20
Average (as % of sham)	–	126.2	11.1*
Noradrenaline concentration (pmol/tissue sample)
Left hemisphere	2.56 ± 0.72	2.24 ± 0.20	0.08 ± 0.04
Right hemisphere	3.00 ± 0.72	2.40 ± 0.36	0.16 ± 0.08
Average	2.80 ± 0.60	2.32 ± 0.12	0.12 ± 0.04
Average (as % of sham)	–	82.9	4.2*
Dorsolateral striatum
DA concentration (pmol/tissue sample)
Left hemisphere	30.60 ± 5.20	25.16 ± 3.28	19.32 ± 4.12
Right hemisphere	30.12 ± 5.00	25.44 ± 6.08	22.88 ± 3.96
Average	30.36 ± 5.00	25.32 ± 4.56	21.08 ± 3.88
Average (as % of sham)	–	83.4	69.4
Noradrenaline concentration (pmol/tissue sample)
Left hemisphere	2.96 ± 0.08	2.84 ± 0.40	1.92 ± 0.24
Right hemisphere	2.88 ± 0.08	2.60 ± 0.40	2.24 ± 0.28
Average	2.92 ± 0.08	0.72 ± 0.40	2.00 ± 0.24
Average (as % of sham)	–	93.2	68.5

Data are expressed as means ± SEM for sham-lesioned animals (craniotomy only) and for animals that received either vehicle or 6-OHDA infusions into the NAc. Percentages relate to the average monoamine concentration across hemispheres with respect to the sham group.

^*P < 0.05.