Table 3.
Concentration of Calpain Inhibitors in the Mouse Brain After Subcutaneous Administration.a
| (µg/g tissue) |
||||
|---|---|---|---|---|
| Compound | (N = 3; 1 hour) | (N = 3; 2 hour) | (N = 3; 4 hour) | (N = 3; 8 hour) |
| 4a | ND | ND | ND | 1.17 ± 0.01b |
| 4d | NQc | 1.14 ± 0.02b | ND | ND |
a
Concentration of 4a and 4d detected in the brain obtained from mice dosed with the inhibitors at 24 mg/kg body weight. The mice received the drug by subcutaneous administration and were sacrificed after 1, 2, 4, and 4 hours. A calibration curve was measures at varying doses of 4a and 4d in mouse plasma. The quantitation limit was 0.16 µg/mL of plasma for 4a and was 0.23 µg /mL plasma for 4d. No calibration curves were determined brain tissue. ND = not detected, NQ = not quantifiable.
b
The value listed is three injections of a sample from one mouse and this group is N = 1. The two other mice were NQ.
c
The inhibitor was detected in all three mice.