Table 1.
ABL-interacting proteins. Human protein names (www.genenames.org) are used throughout, although in some cases the murine gene and protein was reported.
| PROTEIN | DOMAIN | REF | SUB | ALIASES | PARALOGS | FUNCTION COMMENTS |
|---|---|---|---|---|---|---|
| ABI1 | SH3, PxxP | 7590237 | yes | NAP1BP | ABI2,3 | cytoskeleton, ABL kinase reg |
| ABI2 | SH3, PxxP | 7590236 | AblBP3 | ABI1,3 | cytoskeleton, ABL kinase reg | |
| ACR | SH3 | 16446784 | acrosin | protease | ||
| APBB1 | PR | 11279131 | yes | Fe65 | APBB2,3 | transcription adaptor |
| ATM | SH3 | 9168117 | TEL1, ATC | ATR | DNA repair, damage response | |
| ATR | unknown | 15050919 | MEC1, SCKL | ATM | DNA repair, damage response | |
| BCR | SH2 | 1383690 | ABR | signaling, GAP for RAC | ||
| BIN1 | C-term | 9356459 | AMPHL, ALP1 | cytoskeleton, endocytosis | ||
| BRCA1 | SH3 | 12024016 | BRCC1 | DNA repair, damage response | ||
| BTK | unknown | 12445832 | yes | AGMX1, XLA | BMX | tyrosine kinase |
| CABLES1 | SH3+ | 10896159 | yes | ik3-1 | CABLES2 | signal adaptor, cell cycle |
| CABLES2 | unknown | 11955625 | ik3-2 | CABLES1 | signal adaptor, cell cycle | |
| CASP9 | SH3 | 15657060 | yes | CASP2,8,10 | protease, apoptosis | |
| CAV1 | unknown | 16151024 | yes | caveolin | CAV2,3 | membrane protein, endocytosis |
| CBL | SH2, SH3 | 11494134 | yes | CBL2 | CBLB, C | ubiquitin ligase, endocytosis |
| CD19 | unknown | 11120811 | yes | BCR co-receptor | ||
| CDON | SH3 | 19470755 | CDO | BOC | Ig superfamily recpt, adhesion | |
| CPSF6 | SH3 | 8943360 | AAP1, CFIM | cleavage & polyA factor | ||
| CREB1 | SH2, TK | 7565761 | CREB | ATF1, CREM | transcription, cAMP response | |
| CRK | PxxP | 7926767 | yes | CRKL | signal adaptor | |
| CRKL | (PxxP) | 8083188 | yes | CRK | signal adaptor | |
| CTNND1 | SH3 | 11891774 | yes | catenin δ | CTNND2, ARVCF | adhesion, signaling |
| DAB1 | SH2 | 9009273 | disabled | DAB2 | signal adaptor | |
| DDB1 | TK | 12107171 | yes | XPE | DNA repair, complex w/DDB2 | |
| DOK1 | pY | 10567556 | yes | p62Dok | DOK2,3-7 | signal adaptor |
| DOK2 | SH3 | 12777393 | yes | p56Dok | DOK2,3-7 | signal adaptor |
| DOK3 | pY | 10567556 | yes | DOKL | DOK1,2,4-7 | signal adaptor |
| EGFR | SH2 | 7678409 | yes | ERBB1 | ERBB2-4 | tyrosine kinase (receptor type) |
| ENAH | SH3 | 16446784 | yes | MENA | VASP, EVL | cytoskeleton, actin polym |
| EPHB2 | SH2+Cter | 11494128 | yes | Tyro5 | EPHB1,3,4,6 | tyrosine kinase (receptor type) |
| ERBB2 | SH2 | 19275932 | neu, HER2 | EGFR, ERBB3,4 | tyrosine kinase (receptor type) | |
| ERCC6 | SH3 | 17626041 | yes | CSP, CKN2 | ERCC6L | DNA repair |
| ESR1 | SH3 | 20101225 | yes | Era | ESR2 | steroid recpt, transcript. |
| EVL | SH3 | 16446784 | RNB6 | ENAH, VASP | cytoskeleton, actin polym | |
| GPX1 | SH3 | 12893824 | yes | GPX2-8 | glutathione peroxidase | |
| GRB2 | PxxP | 7926767 | yes | NCKAP2 | GRB7,10,14 | signal adaptor |
| GRIN2D | SH3 | 10777567 | NR2D | GRIN2A-C | NMDA recpt., ABL kinase inhib | |
| HCLS1 | SH2 | 18305217 | yes | HS1 | CTTN | cytoskeleton, actin regulator |
| HDAC4 | SH3 | 16446784 | HD4 | HDAC5,7,9 | deacetylase | |
| INPPL1 | SH3 | 10194451 | yes | SHIP2 | INPP5D | phosphoinositide phosphatase |
| JAK1 | C-term | 9774693 | JTK3 | JAK2,3, TYK2 | tyrosine kinase | |
| JAK2 | C-term | 11593427 | yes | JTK10 | JAK1,3, TYK2 | tyrosine kinase |
| JUN | SH2 | 10637231 | yes | AP-1 | JUNB, JUND | transcription |
| LASP1 | SH3 | 15138294 | yes | MLN50 | NEBL | cytoskeleton, cell migration |
| LRRN2 | SH3 | 16446784 | LRRN5, GAC1 | LRRN1,3,4 | leucine rich repeat, signaling | |
| MAP3K1 | SH3 | 10866655 | yes | MEKK1 | MAP3K2-15 | MAPK (JNK) activation, signaling |
| MAP4K1 | SH3 | 9003777 | HPK1 | MAP4K2-5 | MAPK (JNK) activation, signaling | |
| MAP4K5 | unknown | 9949177 | KHS, GCKR | MAP4K1-4 | MAPK (JNK) activation, signaling | |
| MAPT | unknown | 16014719 | yes | tau | cytoskeleton, microtubule dynamics | |
| MDM2 | unknown | 12110584 | yes | MDM4 | DNA damage/apoptosis/signaling | |
| MDM4 | unknown | 19075013 | yes | MDMX | MDM2 | DNA damage/apoptosis/signaling |
| MSH5 | SH3 | 16397227 | yes | MutS hom5 | MSH2-4,6 | DNA repair |
| MUC1 | SH2 | 16888623 | yes | PUM, PEM | barrier function, signaling | |
| MUSK | unknown | 12796783 | yes | tyrosine kinase (receptor type) | ||
| NCK1 | PxxP | 7926767 | yes | NCKalpha | NCK2 | signal adaptor |
| NCK2 | unknown | 10887126 | yes | GRB4, NCKβ | NCK1 | signal adaptor |
| NEDD9 | unknown | 8668148 | yes | HEF1, CAS-L | BCAR1, EFS | signal adaptor |
| NFKBIA | SH2+ | 12167702 | yes | IKBA, NFKBI | NFKBIB, D, E,Z | signaling, NFKB inhibitor |
| NTRK1 | unknown | 10679771 | yes | TrkA | NTRK2,3 | neurotrophic RTK (also 10708759) |
| PAK2 | unknown | 11121037 | yes | PAKgamma | PAK1,3 | S/T kinase |
| PDE4D | SH3 | 10571082 | DPDE3 | PDE4A-C | cAMP phosphodiesterase | |
| PDGFRB | SH2 | 19275932 | yes | PDGFR | PDGFRA | tyrosine kinase (receptor type) |
| PIK3R1 | pYXXM | 8781408 | p85 | PIK3R2-5 | phosphoinositide-3-kinase reg | |
| PLCG1 | SH2, SH3 | 12652307 | yes | PLCgamma | PLCG2 | phospholipase |
| PLSCR1 | SH3 | 11390389 | yes | MMTRA1B | PLSCR2-5 | phospholipid scrablase |
| PLXNA1 | unknown | 18660502 | plexin | PLXNA2-4 | signaling, SEMA response | |
| POLR2A | SH2 | 7533294 | yes | RNA pol. 2 | POLR2B-L | transcription, polymerase |
| PRDX1 | SH3 | 9334312 | PAG, MSP23 | PRDX2-6 | peroxiredoxin, ABL kinase inhib | |
| PRKDC | SH3 | 9312071 | yes | DNAPK | S/T kinase, DNA reapir | |
| PSMA7 | SH2, SH3 | 16678104 | yes | C6, XAPC7 | PSMA8 | proteasome component |
| PSTPIP1 | C-term | 11163214 | yes | PSTPIP | PSTPIP2 | signal adaptor |
| PTK2B | SH2 | 14654952 | FAK2, PYK2 | PTK2 | cytoskeleton, adhesion | |
| PTPN6 | SH3 | 8692915 | yes | SHPTP1 | PTPN11 | tyrosine phosphatase |
| PXN | unknown | 9603926 | yes | paxillin | cytoskeleton, actin regulator | |
| RAD9A | SH3 | 11971963 | yes | RAD9 | RAD9B | DNA repair |
| RAD51 | SH3 | 9461559 | yes | RECA | DNA repair | |
| RAD52 | unknown | 12379650 | yes | DNA repair | ||
| RAN | unknown | 11420673 | yes | TC4 | GTPase, nuclear transport | |
| RAPH1 | SH2 | 20417104 | yes | lamellipodin | cytoskeleton, actin reg | |
| RB1 | TK | 8242749 | yes | RB | cell cycle, inhibits ABL kinase | |
| RFX1 | SH3 | 9583676 | RFX2-8 | transcription factor | ||
| RIN1 | SH2, SH3 | 9144171 | yes | RIN2,3 | RAS effector, RAB & ABL activator | |
| ROBO | unknown | 17618275 | ROBO1-4 | axon guidance receptor | ||
| SEM6A | SH3 | 16446784 | semaphorin | SEMA6B-D | receptor-mediated signaling | |
| SEM6D | SH3 | 16446784 | semaphorin | SEMA6A-C | receptor-mediated signaling | |
| SH3BP1 | SH3 | 1379745 | 3BP1 | SH3BP2,4,5 | Rac GAP | |
| SH3BP2 | SH3 | 1379745 | 3BP2 | SH3BP1,4,5 | TNFalpha regulator | |
| SHC1 | SH2 | 8617726 | yes | SHC, p66 | SHC2-4 | signal adaptor |
| SHD | unknown | 9315092 | yes | signal adaptor | ||
| SHE | unknown | 9315092 | Shg | signal adaptor | ||
| SIVA1 | SH2, SH3 | 11278261 | yes | CD27BP | signaling, apoptosis | |
| SLC9A2 | SH3 | 10187839 | NHE2 | SLC9A1,3-11 | Na+/H+ exchanger | |
| SORBS1 | PxxP | 11374898 | yes | ponsin, CAP | SORBS2,3 | signal adaptor |
| SORBS2 | PxxP | 9211900 | yes | ArgBP2 | SORBS1,3 | signal adaptor |
| SORBS3 | PxxP | 16831423 | yes | vinexin | SORBS1,2 | signal adaptor |
| SOS1 | unknown | 15039778 | yes | SOS2 | GEF for H/K/NRAS | |
| ST5 | SH3 | 9632734 | HTS1 | DENND2A, C, D | MAPK signal regulation | |
| TERT | SH3 | 10837221 | yes | TRT, TP2 | telomerase reverse transcript. | |
| TMEM131 | SH3 | 16446784 | RW1 | transmembrane protein | ||
| TLN2 | SH3 | 19234221 | talin2 | TLN1 | cytoskeleton, integrin signaling | |
| TOPBP1 | DBD | 15961388 | yes | TOP2BP1 | DNA repair | |
| TP53 | C-term | 7651743 | yes | p53 | TP63, TP73 | transcription; apoptosis |
| TP73 | SH3 | 10391251 | yes | p73 | TP53, TP63 | transcription; apoptosis |
| TREX1 | SH3 | 16446784 | AGS1, DRN3 | DNA repair, exonuclease | ||
| TUB | SH2 | 10455176 | yes | tubby | TULP1-4 | transcription, signaling |
| VASP | unknown | 12087107 | yes | ENAH, EVL | cytoskeleton, actin regulator | |
| VAV1 | unknown | 11790798 | yes | VAV | VAV2,3 | Rho GEF |
| WAS | TK | 12899629 | WASP | WASL | cytoskeleton, actin polym | |
| WASF2 | SH3 | 16899465 | yes | WAVE2 | WASF1,3,4 | cytoskeleton, actin regulator |
| WASF4 | SH3 | 16446784 | WASF1-3 | cytoskeleton, actin regulator | ||
| WRN | SH3 | 12944467 | yes | RECQ3 | DNA repair | |
| YLPM1 | SH3 | 16446784 | ZAP3 | assoc. w/PP1 phosphatase | ||
| YTHDC1 | unknown | 15175272 | YT521 | YTHDC2 | splicing factor | |
| YWHA- | RSVpTLP | 15696159 | 14-3-3 | ABDEGHQZ | subcellular localization | |
| ZAP70 | SH2 | 7760813 | SRK, STD | SYK, PTK2 | tyrosine kinase | |
| ZDHHC16 | C-term | 12021275 | yes | APH2 | signaling, apoptosis |
“Domain” indicates site of interaction on ABL, if known. “Ref” provides literature citations as PMID numbers. “Sub” identifies proteins that are also known ABL substrates.