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. 2010 Oct 13;5(10):e13196. doi: 10.1371/journal.pone.0013196

Table 1. Selected characteristics and results of randomized controlled studies examining the effects computerized and internet-based cognitive behaviour therapy for adult depression and anxiety disorders.

Study Conditions N g NNT Bias Risk F-U Adhere/Satisf
MAJOR DEPRESSION
Andersson, 200522 iCBT + therapist support > waitlist + discussion group 75 0.87 2.16 0 26w 63/-
Kessler, 200923 iCBT + therapist support > TAU by GP 297 0.61 2.99 0 16w 73/-
Perini, 200924 iCBT + therapist support > waitlist 48 0.56 3.25 1 - 74/82
Selmi 199025 cCBT > waitlist 36 1.26 1.59 2 9w 100/-
Titov 201026 iCBT + therapist support > waitlist 141 0.99 1.94 1 - 70/87
Wright 200527 cCBT + therapist support > waitlist 45 1.10 1.77 1 26w 87/-
PANIC DISORDER
Carlbring, 200128 iCBT > waitlist 41 0.99 1.94 1 - 80/85
Carlbring, 2006 29 iCBT > waitlist 60 1.13 1.74 0 39w 80/97
Klein, 2001 30 iCBT > Self-monitoring control 23 0.39 4.59 2 - 90/-
Klein, 200631 iCBT > Information control 55 1.49 1.41 1 13w 90/-
Richards, 200632 iCBT > Information control 32 0.74 2.50 0 13w 82/-
Wims 201033 iCBT + therapist support > waitlist 59 0.28 6.41 1 4w 79/-
SOCIAL PHOBIA
Andersson, 200634 iCBT > waitlist 64 0.76 2.44 0 52w 56/-
Berger et al. 200935 iCBT > waitlist 52 0.64 2.86 1 - 90/85
Botella et al. 200936 iCBT > waitlist 52 1.07 1.82 2 52w 48/-
Carlbring, 200737 iCBT > waitlist 57 1.07 1.82 1 52w 93/-
Furmark et al 200938 iCBT + therapist support > waitlist 120 0.67 2.75 0 52w 97/70
Titov, 2008 I39 iCBT + therapist support > waitlist 105 0.94 2.02 1 26w 78/100
Titov, 2008 II40 iCBT + therapist support > waitlist 88 1.18 1.68 1 26w 81/100
Titov, 2008 III41 iCBT + therapist support > waitlist 98 1.02 1.89 1 - 77/-
GAD
Titov 200942 iCBT + therapist support > waitlist 48 1.08 1.81 1 - 75/85
Robinson 201043 iCBT + therapist support > waitlist 150 1.13 1.74 1 - 74/87

N, number randomized; g, Hedges g; NNT number needed to treat; Bias risk (0 = no risk, 5 =  high risk) inadequacy of sequence generation, no allocation concealment, inadequate blinding, missing data not addressed, selective reporting; F-U, follow-up in weeks; Adhere/satisfaction, percent adhering to whole course/percent satisfied with course; iCBT, CBT over the internet; cCBT, CBT over computer in clinic; GAD, Generalized Anxiety Disorder.