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. 2010 Oct 13;5(10):e13047. doi: 10.1371/journal.pone.0013047

Figure 6. Human anti-F1and anti-V mAbs show synergistic protection when used together in the murine bubonic plague model.

Figure 6

The human and mouse anti-F1 and anti-V mAbs were given i.p. to mice 24 hrs before parenteral challenge with Y. pestis CO92, and the number of surviving mice for each treatment group was monitored for 21 days after challenge. 6A. The following antibodies and amounts were used: normal mouse serum (NMS, 500 µg); mouse anti-F1 (F1m, 500 µg); mouse anti-V (7.3 m, 100 µg); human anti-F1 (m252, 500 µg); human anti-V (m253 and m254, 500 µg each). 6B. The following mAbs and amounts were used: NMS, 500 µg; F1m, 500 µg; m252, 500 µg; m253+ m254, 500 µg each; m252+ m253+ m254, 500 µg each.