Table 1. Anopheles gambiae genes related to Drosophila aging.
| Probe Set ID | Age effect* | Bloodfeeding effect† | Functional group | Functional assignment | Best match to DMPROT database |
| Ag.2L.458.0_CDS_a_at | ↑ | no | Cellular Process | C-type lysozyme | CG11159 ‡ |
| Ag.3R.713.0_CDS_s_at | ↑ | no | Detoxification | Cytochrome P450 | Cyp6d4 |
| Ag.X.268.0_CDS_a_at | ↑ | no | Detoxification | Cytochrome P450 | Cyp4d2 |
| Ag.X.7.0_CDS_at | ↑ | no | Detoxification | Cytochrome P450 | Cyp9f2 |
| Ag.3L.178.0_CDS_s_at | ↑ | no | Metabolism | Peptide methionine sulfoxide reductase | Eip71CD ‡ |
| Ag.2L.1715.0_CDS_at | ↑ | no | Regulation | Putative GTPase activating protein for Arf | Git ‡ |
| Ag.2L.29.0_CDS_a_at | ↑ | no | Response to Stress | Lysozyme precursor | CG7798 |
| Ag.2R.1515.1_CDS_a_at | ↓ | no | Cellular Processes | Autophagic cell death | Ect3 |
| Ag.2R.365.0_CDS_a_at | ↓ | no | Metabolism | Formate-tetrahydrofolate ligase | pug ‡ |
| Ag.2L.1721.0_CDS_at | ↓ | no | Metabolism | Rossmann-fold NAD(P)(+)-binding proteins | Pdh |
| Ag.3L.433.0_CDS_at | ↓ | no | Metabolism | PurM-like; AIR (aminoimidazole ribonucleotide) synthase related protein. | SelD |
| Ag.2L.284.0_CDS_at | ↓ | no | Metabolism | Acyltransferase | Taz ‡ |
| Ag.3R.169.0_UTR_s_at | ↓ | no | Transport | EF-hand, calcium binding motif | Scp1 * |
| Ag.3L.353.0_CDS_s_at | ↑ | ↓ | Detoxification | Cytochrome P450 (Fragment) | Cyp9b2 |
| Ag.3R.739.0_CDS_at | ↑ | ↓ | Detoxification | Cytochrome P450 | Cyp4c3 |
| Ag.2R.46.0_CDS_at | ↑ | ↓ | Metabolism | GST_C family, Class Delta and Epsilon subfamily, cellular detoxification | GstD1 |
| Ag.2R.70.0_CDS_at | ↑ | ↓ | Transport | Pheromone-binding protein | Pbprp2 |
| Ag.UNKN.1744.0_CDS_s_at | ↓ | ↑ | Cellular Processes | Autophagic cell death | crq ‡ |
| Ag.3L.1690.0_CDS_at | ↓ | ↑ | Metabolism | Oligosaccharide biosynthesis | pgant6 |
| Ag.2R.399.0_CDS_a_at | ↓ | ↑ | Response to Stress | Heat shock 70 kDa protein | Hsc70-3 ‡ |
| Ag.3R.644.0_CDS_a_at | ↓ | ↓ | Structural | Chitin_bind_4; Insect cuticle protein | Cpr49Ae ‡ |
Genes with expression variation associated with aging are conserved among Anopheles gambiae and Drosophila melanogaster.
*Age effect:” ↑ ” indicates monotonically increasing expression with mosquito age, and “↓“ monotonically decreasing expression.
†
Bloodfeeding effect: “no” indicates no effects by bloodfeeding on gene expression, “ ↑ ” pp-regulation by blodfeeding, and “ ↓ “ down-regulation by bloodfeeding.
‡
Drosophila melanogaster homologous gene name.